| 세션명 | 대학원생 구두발표 (II) |
|---|---|
| 발표장 | 제10회장 (105) |
| 논문코드 | 1O10-2 |
| 발표일 | 2018-10-11 |
| 발표시간 | 13:45-14:00 |
| 논문제목 | ROS-responsive thioether-based polymers for cancer-targeted therapy |
| 발표자 | 김윤석 |
| 발표자 소속 | 인천대학교 생명 나노바이오공학 |
| 저자 | 김윤석, 김수민1, 심민석2,† |
| 소속 | 인천대학교 생명 나노바이오공학; 1가톨릭대학교 약학대학; 2인천대학교 |
| 논문초록 | Piperlongumine (PL) has attracted attention for promising pro-oxidant anticancer agent that can induce increase in intracellular reactive oxygen species (ROS). PL exhibits cancer-specific cytotoxicity via enhancement of intracellular ROS concentration in cancer cells, However, its poor solubility in aqueous solution is a critical drawback to compromise its therapeutic efficacy. To overcome this, we developed low-toxic ROS-responsive thioether-bearing polymer (TEP) to effectively deliver PL to cancer cells. TEP bears ROS-sensitive sulfide and ester groups. TEP successfully formed nanoparticles encapsulating PL (PL-TEP NPs). Importantly, PL-TEP NPs revealed superior cytotoxicity in human breast cancer cells (MCF-7) over normal human dermal fibroblast cells (hDFB). This study demonstrates that TEP-based nanoparticles are effective and low-toxic ROS-responsive drug carriers for hydrophobic PL, and PL-TEP NPs have high potential for cancer-specific pro-oxidant therapy. |
THE POLYMER SOCIETY OF KOREA